Steven L. McKnight, Ph.D. 
Professor of Biochemistry
UT Southwestern Medical Center 

Abstract:
Nuclear and cytoplasmic puncta, including Cajal bodies and various forms or RNA granules, were first observed over a century ago. Evidence will be presented indicating that these and related puncta are organized via the reversible polymerization of low complexity polypeptide sequences associated with RNA regulatory proteins and transcription fators. These observations afford the conceptualization of a solid state theory of information transfer in eukaryotic cells.