The cell cycle control logic in Caulobacter drives an integrated system that operates in time and space. Oscillating levels of a small number of temporally-controlled master regulators enable multiple cell cycle functions. Cell cycle regulation is, to a...
During the last few decades, scientists have begun to solve one of the greatest puzzles of all time: Why do we age? It turns out that aging, like so much else in biology, is subject to regulation by the genes; in this case, by genes encoding familiar...
The molecular details of biological processes can be most accurately understood by probing biomolecules within their native habitats in cells, or even better, live organisms. To interrogate biomolecules in such complex settings requires the means to...
We study the molecular basis of cellular motility, endocytosis and cytokinesis. We use fission yeast for much of this work because they use the same molecular mechanisms at humans, but are much more amenable to experimentation using molecular genetics. We...
Pungent irritants from pepper, mint, and mustard plants have served as powerful pharmacological probes for identifying molecules, cells, and circuits that contribute to somatosensation and pain. These natural products elicit pain by targeting members of...
