#  Edsall Lectures 

 



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### 2016

2016. “[Life Without Heterochromatin: Insights into Stabilizing the Genome](/presentations/life-without-heterochromatin-insights-stabilizing-genome)”



 

 

2016. “[Life Without Heterochromatin: Insights into Stabilizing the Genome](/presentations/life-without-heterochromatin-insights-stabilizing-genome)”



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
Histone H3K9 methylation is a conserved modification that correlates broadly with gene repression in organisms ranging from fission yeast to man. In C. elegans, di- and tri-K9 methylation is abundant on repetitive elements (RE), including both transposons...



 

 

 

 



### 2014

2014. “[Viral Noncoding RNAs: Insights into Evolution](/presentations/%E2%80%9Cviral-noncoding-rnas-insights-evolution%E2%80%9D)”



 

 

2014. “[Viral Noncoding RNAs: Insights into Evolution](/presentations/%E2%80%9Cviral-noncoding-rnas-insights-evolution%E2%80%9D)”



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
Like host cells, some viruses produce noncoding RNAs that contribute to the viral life cycle or help the virus evade the defenses the host organism raises against infection. We have been studying a variety of noncoding RNAs made by gamma herpesviruses, a...



 

 

 

2014. “[New Enzymes by Evolution: Expanding Nature’s Catalytic Repertoire](/presentations/%E2%80%9Cnew-enzymes-evolution-expanding-nature%E2%80%99s-catalytic-repertoire%E2%80%9D)”



 

 

2014. “[New Enzymes by Evolution: Expanding Nature’s Catalytic Repertoire](/presentations/%E2%80%9Cnew-enzymes-evolution-expanding-nature%E2%80%99s-catalytic-repertoire%E2%80%9D)”



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
Enzymes are admired for their ability to selectively catalyze myriad transformations. We use laboratory evolution experiments to understand better how evolution modifies existing enzymes and creates new ones. A powerful approach to engineering biological...



 

 

 

 



### 2013

2013. “[Physical Mechanisms of Cell Organization on Micron Length Scales](/presentations/%E2%80%9Cphysical-mechanisms-cell-organization-micron-length-scales%E2%80%9D)”



 

 

2013. “[Physical Mechanisms of Cell Organization on Micron Length Scales](/presentations/%E2%80%9Cphysical-mechanisms-cell-organization-micron-length-scales%E2%80%9D)”



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
Cells are organized on length scales from Angstroms to microns. However, the mechanisms by which Angstrom-scale molecular properties are translated to micron-scale macroscopic properties are not well understood. We have shown that interactions between...



 

 

 

 



### 2012

2012. “[The Mechanism of Signaling by the T Cell Receptor](/presentations/mechanism-signaling-t-cell-receptor)”



 

 

2012. “[The Mechanism of Signaling by the T Cell Receptor](/presentations/mechanism-signaling-t-cell-receptor)”



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide-bound MHC (pMHC) on an infected cell. The mechanism by which this interaction triggers intracellular phosphorylation of the TCR, which lacks a kinase...



 

 

 

 



### 2011

2011. “[Core Transcription Factors, Embryonic Stem Cells and Differentiation](/presentations/core-transcription-factors-embryonic-stem-cells-and-differentiation)”



 

 

2011. “[Core Transcription Factors, Embryonic Stem Cells and Differentiation](/presentations/core-transcription-factors-embryonic-stem-cells-and-differentiation)”



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
Deciphering the molecular basis of pluripotency is fundamental to our understanding of mammalian development and embryonic stem cell biology. Will discuss novel transcriptional mechanisms governing ESC gene expression and describe core promoter...